Pharmacology Research Scientist Apply
Job Description
The Pharmacology Research Scientist will design, execute, and interpret in vivo, ex vivo, and in vitro assays in primary cells to study the action of compounds on disease-relevant biology. They can complete work efficiently and independently, and design alternative approaches to achieve desired outcomes. They keep up to date on the scientific literature relevant to their field(s) of technical expertise. This level captures both the Research organizations entry level for staff with a research doctoral degree (PhD) and the advanced experimental expert leading one or more critical laboratory functions with high impact on drug discovery projects. This is an onsite position at our San Diego research site.
Key Duties and Responsibilities
- Plans and executes elaborate pharmacology experiments in vivo, ex vivo and in vitro in primary cells
- Collates and interprets complex data and synthesizes results to guide Project decisions and new research activities
- Exercises solid judgment to prioritize studies, considering feasibility and Project impact
- Performs advanced experimental troubleshooting
- Scours relevant scientific literature and routinely incorporates new insights into research activities
- Identifies, prioritizes and introduces relevant emerging technologies in his/her field of expertise to advance internal technology platforms and to create/maintain a competitive advantage
- Explores the feasibility of applying new scientific concepts or implements and validates novel experimental approaches and technologies to achieve project goals
- Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings
- Contributes to patent and/or publication preparation
- Performs other duties as assigned
Required Knowledge/Skills
- Deep knowledge of the physiology of lung, kidney, liver, and/or peripheral nervous system
- Experience with primary ex vivo preparations (i.e., precision cut organ slices), including dissection, culture, pharmacokinetic and functional assessment
- Firm understanding of principles of pharmacokinetics and pharmacology
- Hands-on experience with mouse handing, dosing, and tissue collection
- Hands-on experience with cryosectioning, autoradiography, immunohistochemistry and in situ hybridization experience
- Experience designing and executing complex, challenging assays that measure the action of compounds on in vitro or in vivo disease biology
- A broad working knowledge of fundamental pharmacology principles
- Astute understanding of his/her own discipline and the relevant literature
- Maintains high level of knowledge of current developments in the scientific Project field
- Displays proven productivity and experimental creativity, and effective dissemination of ideas
- Demonstrates effective communication skills, especially in peer-directed presentations
- Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas
Education and Experience:
- Typically requires a PhD and 0-3 years of experience or,
- Typically requires a Masters degree and 3 years of experience or,
- Typically requires a Bachelors degree and 6 years of experience
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Salary range: $102,960 - $154,440 annually
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.
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