About Prolerity

Prolerity provides centralized operational, financial, and strategic services to support a growing clinical research network. Our work enables high-quality, efficient clinical research by bringing rigor, transparency, and insight into complex operational environments. The Finance team plays a critical role in supporting informed decision-making, financial discipline, and scalable growth across the network.

Position Summary

The PMO Manager is responsible for overseeing and governing the health, execution, and performance of clinical research projects across a network of clinical trial sites. This role ensures projects are delivered on time, within scope, and in compliance with sponsor, and organizational standards throughout the full project lifecycle

The PMO Manager establishes and maintains standardized processes, and performance metrics to ensure consistent project delivery, transparency, and continuous improvement. This role serves as a partner to Business Development, clinical operations, site leadership, and vendors, supporting operational excellence and scalable growth.

Key Responsibilities

• Lead process mapping, root-cause analysis, and continuous improvement initiatives to enhance efficiency, predictability, and quality.
• Develop and maintain SOPs, workflows, templates, tools, and best practices.
• Provide end-to-end oversight of clinical research projects to ensure overall project health
• Develop and maintain integrated project plans, timelines, and milestones, monitoring progress against commitments.
• Identify, assess, and proactively mitigate risks and issues that may impact timelines, quality, or budget.
• Ensure consistent project reporting, status updates, and visibility for leadership and key stakeholders.
• Design, implement, and continuously improve standardized PMO processes, methodologies, and process flows across the project lifecycle.
• Define and track PMO metrics, dashboards, and KPIs related to project performance, delivery health, and operational efficiency.
• Oversee study start-up activities as part of the broader project lifecycle, ensuring alignment with overall project plans and governance standards.
• Ensure smooth transitions between feasibility, award, start-up, execution, and closeout phases.
• Partner with Business Development to support pre-award feasibility, operational input, and transition from award to execution.
• Serve as a central coordination point across Business Development, clinical operations, regulatory, site leadership, and external partners.
• Qualify, onboard, and manage study-related vendors, ensuring performance aligns with project needs and PMO standards.
• Monitor vendor deliverables, timelines, and quality, escalating issues as needed to protect project health.

Required

• Bachelor’s degree in life sciences, healthcare, business, or a related field (or equivalent experience).
• PMO or Project Management certification required (e.g., PMP, PgMP, PMI-ACP, PRINCE2, or equivalent).
• 5+ years of experience in clinical research, project management, or PMO leadership roles.
• Proven ability to lead process improvement and standardization initiatives.
• Experience managing clinical trial vendors and external partners.
• Strong understanding of clinical trial operations across the study lifecycle.
• Demonstrated experience managing complex, cross-functional projects and maintaining overall project health.
• Excellent communication, organizational, and problem-solving skills.

Preferred

• Experience working within a clinical trial site network, Sponsor, or CRO environment.
• Formal training or experience in Lean, Six Sigma, or other continuous improvement methodologies.