Location : IC : NCATS Street: 9800 Medical Center Dr-Bldg C Bldg: 9800 Medical Center Bldg C Room: 217W City: Rockville State & Zip: MD 20850

Weekly Hours - FT: 30-40 hours per week Total No. of Hours : 40

Overall Position Summary and Objectives

The successful candidate will possess a deep knowledge of scale-up and process chemistry skills for the development of safe and scalable synthetic routes, with early and late-phase development experience and delivering drug substances under tight timelines.

Min Education - Master's

Resume Max Pages - 3

ADDITIONAL QUALIFICATIONS

Certifications & Licenses

• Good Manufacturing Practice (GMP)

Skills (Ranked By Priority)

1. Process development and scale-up synthesis
2. Cheomatography (HPLC, GC. etc)
3. Nuclear Magnetic Resonance
4. Manuscript writing
5. Equipment Maintenance

1, 2, 3, 4, 5 represents priority rankings, where 1 is highest priority and 5 is lowest priority of those ranked

Software

• PowerPoint
• E-Notebook
• Chemdraw
• MestReNova
• Outlook
• Excel
• Word

Field of Study

• Chemistry

Statement of Work Details

Provides laboratory experience needed to assist in performing various chemical experiments and procedures.

• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models. 3
• Perform chemical and biochemical reactions and appropriate analytical analyses. 5
• Design and develop safe and scalable processes for organic compounds of specific therapeutic targets 1
• Purify organic compounds using a variety of techniques including chromatography, extraction, distillation, crystallization, trituration, etc. 4
• Synthesize key intermediates and drug substances from gram to kilogram scale. 2

Utilizes and operates various complex laboratory machines and equipment.

• Perform general maintenance and upkeep of equipment and instrumentation.
• Troubleshoot and provide routine maintenance of the instruments and equipment.
• Identify the cause of common problems and mistakes and make necessary repairs.

Documents and analyzes results, produces detailed summaries and reports.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals.
• Maintain up-to-date electronic laboratory notebook detailing all experiments.
• Collect and review data; analyze and interpret data and results.
• Produce research reports and communicate results.
• Search chemical databases for journal articles, patents and related technologies.

Analyzes organic and inorganic compounds to determine chemical and physical properties, composition, structure, relationships between compounds, and reactions.

• Manage bulk-synthesis, purification and formulation efforts for advanced testing in animal models.
• Work with staff in identity, purity and stability analysis.
• Analyze and characterize organic compounds using state-of-the art analytical technologies;

Adds heat, light, energy or a catalyst to show changes in composition.

• Purify compounds by preparative chromatography from chemists.

Provides laboratory experience needed to perform various complex chemical experiments and procedures.

• Perform bulk-synthesis, purification and formulation efforts for advanced testing in animal models.
• Perform chemical and biochemical reactions and appropriate analytical analyses.
• Design and develop safe and scalable processes for organic compounds of specific therapeutic targets- Synthesize key intermediates and drug substances from gram to kilogram scale.
• Purify organic compounds using a variety of techniques including chromatography, extraction, distillation, crystallization, trituration, etc.

Prepares test solutions, compounds, and reagents and maintains necessary laboratory supplies.

• Maintain and provide updates on laboratory stockroom and equipment maintenance.
• Inventory all chemicals; maintain and provide updates on all shipping and receiving requests.
• Keep an active inventory of all chemicals kept in the laboratory.

Schedules, tracks and reports analyses of experiments and procedures.

• Maintain computer database for various records.

Independently provides laboratory experience needed to perform various complex chemical experiments and procedures.

• Develop new analytical and separation techniques for the solution of scientific questions.

Designs and optimizes chemical experiments and procedures.

• Develop and document new procedures.
• Develop novel chemistry methodologies and technologies that advance the field and make recommendations.
• Collaborate with staff to evaluate and/or develop new techniques.
• Perform comparative studies with older technology. Perform evaluations to determine new guidelines.
• Develop and present plans for novel syntheses and approaches to new compounds.
• Develop experimental procedures and research protocols.

Trains staff on new experiments and practices, operations and maintenance of instruments and equipment, safety practices, etc.

• Train staff on new experiments, practices, operation and maintenance of instruments and equipment and safety practices.
• Train junior laboratory staff in the design and execution of proper chemical/biochemical protocols.
• Maintain and perform training on scientific instrumentation and equipment.
• Work with staff on all mandatory training and competency assessments.
• Organize and mentor staff in the use of instrumentation.
• Work with facilities manager on evacuation procedures and drills.

Designs, optimizes, and troubleshoots chemical experiments and procedures.

• Develop and document new procedures.
• Develop novel chemistry methodologies and technologies that advance the field and make recommendations.
• Perform comparative studies with older technology. Perform evaluations to determine new guidelines.
• Perform evaluations to determine new guidelines.
• Develop and present plans for novel syntheses and approaches to new compounds.
• Develop experimental procedures and research protocols.

Manages overall maintenance of laboratory.

• Work with staff to monitor and manage waste disposal.
• Monitor and report on all safety issues.
• Carry out periodic lab surveys; dispose of radioactive and chemical waste according to Institutional and regulatory procedures.
• Participate in laboratory clean-up events and aid laboratory managers in organizing stock-rooms and bench areas.
• Maintain staff safety records for compliance.
• Maintain records or quarterly safety inspections.
• Coordinate laboratory and network obligations.

Provides scientific expertise needed in order to function as the senior chemist of a large laboratory.

• Design synthetic routes to target molecules.
• Synthesize, purify and characterize target molecules.
• Provide chemistry support for multiple projects.
• Present research findings at group meetings, project meetings and conferences.
• Coordinate projects being developed by external collaborators, propose SAR strategies and monitor their progress.
• Perform a variety of chemical techniques and advanced analysis to complete studies and experiments.
• Develop new analytical and separation techniques for the solution of scientific questions.

Maintains, operates and calibrates numerous machines for use in various experiments and procedures.

• Perform general maintenance and upkeep of equipment and instrumentation.
• Troubleshoot and provide routine maintenance of the instruments and equipment.
• Monitor, troubleshoot and initiate or take corrective action to maintain instrument function and quality.
• Identify the cause of common problems and mistakes and make necessary repairs.

Assesses methods and procedures for use in experiments and makes modifications and improvements to resolve problems and meet specific needs.

• Develop experimental procedures and research protocols.
• Develop novel chemistry methodologies and technologies that advance the field.
• Collaborate with staff to evaluate and/or develop new techniques.
• Carry out scale-up of the chemical probes of interest for additional studies.

Maintains accurate, detailed records of experiments, and evaluates and interprets results for validity and scientific meaning.

• Maintain a comprehensive notebook and analytical data for each compound synthesized.
• Interpret data; use evolving activity and data to design additional rebounds of analogs.
• Conduct and write literature reviews for current and future projects.
• Collect and review data; analyze and interpret data and results.
• Search chemical databases for journal articles, patents and related technologies.

Works with staff to prepare laboratory findings for publication and presentation at meetings.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals.
• Prepare summaries, reports and presentations based on findings.
• Contribute to publications and patent writing.
• Produce research reports and regularly communicate results.
• Search chemical databases for journal articles, patents and related technologies.