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Job Summary:

The Research Scientist will play key roles in identifying research problems and developing research methodologies and procedures, implementing in vitro and in vivo experiments and training students.

The Engin Laboratory within the Department of Biomolecular Chemistry (BMC) is focused on understanding how cellular stress response and organelle dysfunction plays a role in beta cell physiology and pathology. Current projects involve studying molecular mechanisms of cellular stress responses in pancreatic beta cells in autoimmune diabetes, ER-mitochondria communication, lysosome dysfunction, cellular senescence and the crosstalk between stressed beta cells and immune cells. The work involves working with the beta cell or immune cell-specific mouse models of the unfolded protein response pathway and mechanistic studies using cell culture (primary mouse and human islets), biochemical and immunological assays (Engin et al., Sci Transl Med 2013, Lee et al, Cell Metab 2020, Chen, et al., Nat Comm 2022). More information about our research and publications can be found at enginlab.org.

Candidates should have demonstrated ability to work effectively in a collaborative manner with faculty and staff, as well as other institutional representatives; strong organizational, written, and verbal communication skills in English; high levels of critical thinking, excellent technical skills, and a strong track-record of accomplishment and productivity in research as evidenced by high-quality publications related to physiology, immunology, metabolism, cell signaling/signal transduction and disease mechanisms.

Since our inception in 1921, BMC has celebrated 100 years of discovery related to biochemical research, integrating fundamental molecular mechanisms with human disease, within the University of Wisconsin School of Medicine and Public Health.

Of the 16 faculty, five affiliate faculty, and emeritus faculty, several have been recognized with national and international honors, including by the National Academy of Sciences, American Academy of Arts and Sciences, American Academy of Microbiology, and American Association for the Advancement of Science.

The department is housed within the Hector Deluca Biochemical Sciences complex, a state-of-the-art research and instructional complex located on Henry Mall, and has a reputation for carrying out federally funded, high level, competitive biomedical research. Visit https://bmolchem.wisc.edu/ to learn more.

Responsibilities:

Scientist I (RE043)
Scientist II (RE044)

Institutional Statement on Diversity:

Diversity is a source of strength, creativity, and innovation for UW-Madison. We value the contributions of each person and respect the profound ways their identity, culture, background, experience, status, abilities, and opinion enrich the university community. We commit ourselves to the pursuit of excellence in teaching, research, outreach, and diversity as inextricably linked goals.

The University of Wisconsin-Madison fulfills its public mission by creating a welcoming and inclusive community for people from every background - people who as students, faculty, and staff serve Wisconsin and the world.

For more information on diversity and inclusion on campus, please visit: Diversity and Inclusion

Education:

Required
Terminal Degree
Ph.D. in the biochemical sciences with an emphasis on either molecular biology, cell biology, immunology, genetics, or closely related field required.

Qualifications:

Requirements

• 3 years minimum of post-doctoral research experience in molecular biology, biochemistry, cell biology, genetics, or immunology in an academic or similar research environment is required.
• At least 2 first-author papers in science high impact journals in the last 5 years
• Expertise in two or more of following skills/techniques is required:
• Pancreas biology: Islet isolation, human islet culturing and experimenting, islet histomorphometry.
• Mammalian cell culture: siRNA, transfection, stable cell line generation, gene manipulations with CRISPR/Cas9.
• Experience with basic molecular biology and biochemistry methods including, isolation RNA and protein from tissues and cells, qPCR and Western Blot, ChIP, ELISA, microscopy and cloning,
• Immunology: Multicolor FACS analysis, FlowJo analysis, adoptive transfers.
• Prior experience on working with mouse models: Colony management, drug administration (via i.p, sub-Q, i.g injections or via oral gavage), and dissection of the organs.
• Experience with AAV vectors, transduction or mouse injection
• Prior experience on handling large data sets and bioinformatic analysis: single cell RNAseq, scATACseq etc.

Preferences

• Experience working with transgenic mouse colonies is highly desired.
• Previous experience in cellular signaling/signal transduction, organelle biology, disease mechanisms and metabolism is highly desired. However, candidates trained in other fields such as molecular biology, biochemistry, bioinformatics, cell biology, genetics or immunology with translatable skills will also be considered.

Work Type:

Full Time: 100%

Appointment Type, Duration:

Ongoing/Renewable

Salary:

Minimum $60,000 ANNUAL (12 months)
Depending on Qualifications

Additional Information:

Applicants for this position will be considered for the titles listed in this posting. The title is determined by the experience and qualifications of the finalist.

The successful applicant will be responsible for ensuring eligibility for employment in the United States on or before the effective date of the appointment. University sponsorship is not available for this position.

How to Apply:

To apply for this position, please click on the \\\\\\\\\\\\\\\"Apply Now\\\\\\\\\\\\\\\" button. You will be asked to upload a current resume/CV and a cover letter briefly describing your qualifications and experience. You will also be asked to provide contact information for three (3) references, including your current/most recent supervisor during the application process. References will not be contacted without prior notice.

Contact:

Melissa Zhang
melissa.zhang@wisc.edu
608-263-0496
Relay Access (WTRS): 7-1-1. See RELAY_SERVICE for further information.

Official Title:

Scientist I(RE043) or Scientist II(RE044)

Department(s):

A53-MEDICAL SCHOOL/BIOMOLEC CHEM/BIOMOL CHM

Employment Class:

Academic Staff-Renewable

Job Number:

293236-AS

The University of Wisconsin-Madison is an Equal Opportunity and Affirmative Action Employer.

Qualified applicants will receive consideration for employment without regard to, including but not limited to, race, color, religion, sex, sexual orientation, gender identity, national origin, age, pregnancy, disability, or status as a protected veteran and other bases as defined by federal regulations and UW System policies. We promote excellence through diversity and encourage all qualified individuals to apply.

If you need to request an accommodation because of a disability, you can find information about how to make a request at the following website: https://employeedisabilities.wisc.edu/disability-accommodation-information-for-applicants/

Employment will require a criminal background check. It will also require you and your references to answer questions regarding sexual violence and sexual harassment.

The University of Wisconsin System will not reveal the identities of applicants who request confidentiality in writing, except that the identity of the successful candidate will be released. See Wis. Stat. sec. 19.36(7).

The Annual Security and Fire Safety Report contains current campus safety and disciplinary policies, crime statistics for the previous 3 calendar years, and on-campus student housing fire safety policies and fire statistics for the previous 3 calendar years. UW-Madison will provide a paper copy upon request; please contact the University of Wisconsin Police Department.