Scientist II - Analytical Development (Lipid Nanoparticles / LNPs)

BEPC is actively looking for a Scientist II in the San Diego, CA area!

W2 Contract – 6 months with possible extensions!

Benefits include medical, dental, vision, and life insurance.

Pay Rate: $50.00 – $57.47/hour – Determined based on experience (Paid Weekly)

Work Model: Fully Onsite

Work Location: San Diego, CA

Location Requirement: Candidates must currently reside within a reasonable commuting distance of the San Diego, CA worksite and be available to work fully onsite. Relocation is not available for this position.

Note: This is a W2 only role — C2C, C2H will not be considered.

Summary of the Position

BEPC is seeking a highly motivated Scientist II to join our client’s site in San Diego, CA. This role will support the Gene Medicines team in the analytical characterization of novel lipid nanoparticle (LNP)-based pharmaceuticals for in vivo genome editing and gene therapy applications.

The ideal candidate will have strong hands-on experience with High-Performance Liquid Chromatography (HPLC), particularly reverse-phase methods, and Biolayer Interferometry (BLI). This position focuses on analyzing nucleic acid-encapsulating lipid nanoparticles, developing analytical methods, and evaluating the relationship between nanoparticle physicochemical properties, efficacy, and safety.

Main Duties and Responsibilities

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• Perform analytical characterization of lipid nanoparticles (LNPs) encapsulating nucleic acids and their components using HPLC and Biolayer Interferometry (BLI), under the direction of analytical scientists.
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• Develop analytical methods to characterize LNPs and their components.
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• Establish relationships between the physicochemical characteristics of experimental nanoparticle formulations and their efficacy and safety.
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• Maintain accurate, detailed records of analytical experiments, results, and supporting data.
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• Collaborate and communicate directly with cross-functional teams to support research activities.
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• Support basic laboratory management activities, including supply ordering, instrument calibration, and maintaining laboratory schedules.
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• Contribute to multiple research projects within a collaborative scientific environment.
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Main Qualifications

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• Education: Master's or Bachelor's degree with 5+ years of experience in Pharmaceutical Sciences, Bioengineering, Chemical Engineering, Chemistry, or a related scientific discipline. An equivalent combination of education and experience may be considered.
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• HPLC Experience: Demonstrated hands-on experience developing analytical methods using gradient-elution HPLC, including reverse-phase (RP), ion-pair reverse-phase (IPRP), or anion-exchange (AEX) chromatography.
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• Biolayer Interferometry (BLI): Hands-on experience with BLI, identified by the hiring manager as a key technical requirement.
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• Analytical Skills: Strong attention to detail and ability to generate accurate, consistent, and reproducible analytical results.
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• Software Proficiency: Proficiency in Microsoft Excel and general office applications.
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• Communication: Excellent written and verbal communication skills, including the ability to effectively communicate analytical findings.
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• Collaboration: Ability to work effectively in a team-oriented, collaborative scientific environment.
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• Organization: Strong multitasking and organizational skills, with the ability to manage multiple projects simultaneously.
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Preferred Qualifications

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• Experience with Surface Plasmon Resonance (SPR).
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• Experience with Liquid Chromatography–Mass Spectrometry (LC-MS).
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• Familiarity with advanced analytical software such as GraphPad Prism or JMP.
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About BEPC

BEPC Inc., founded in 2007, is a 100% employee-owned company providing top-tier consulting and staffing solutions across industries like technology, engineering, manufacturing, and project management. At BEPC, we are driven by innovation and a commitment to excellence. We take pride in fostering a collaborative and innovative environment where our team members thrive. With competitive benefits, including medical, dental, vision, and life insurance, BEPC is dedicated to supporting our employees' personal and professional growth.

Apply Now!

Qualified candidates are encouraged to apply by submitting an up-to-date resume that highlights how your experience aligns with the role. Please include specific examples that demonstrate your qualifications. We look forward to connecting with you!