Scientist

Job Title: Scientist II – Analytical Chemistry (Lipid Nanoparticles / HPLC)Location: San Diego, CA 92111 (Onsite)Employment Type: Full-Time Contract (W2)Duration: 6 Months (Possibility of extension)About the RoleWe are seeking an experienced and detail-oriented Scientist II – Analytical to join an innovative Gene Medicines team in San Diego, CA. In this role, you will play a critical part in the development, characterization, and analysis of novel Lipid Nanoparticles (LNPs) encapsulating nucleic acids for in vivo genome editing and gene therapy applications.You will work closely with cross-functional teams using high-performance liquid chromatography and novel biophysical characterization tools to establish relationships between nanoparticle formulation characteristics, efficacy, and safety.Key ResponsibilitiesAnalytical Characterization: Analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and individual LNP components using Advanced High-Performance Liquid Chromatography (HPLC) modalities and Biophysical Characterization tools.Method Development: Develop and optimize analytical methods to characterize LNP formulations, stability, and therapeutic delivery components.Data & Efficacy Correlation: Establish relationships between the physicochemical characteristics of experimental nanoparticle formulations and their biological efficacy and safety profiles.Data Management: Maintain comprehensive, compliant, and detailed laboratory records of all analytical data.Cross-Functional Collaboration: Interface directly with research, formulation, and scientific teams to share findings and advance pipeline projects.Lab Management: Share responsibilities for general lab operational activities, including instrument calibration, routine maintenance schedules, and supply ordering.Must-Have Qualifications (Required)Education & Experience: Bachelor’s Degree (BS) or Master’s Degree (MS) in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Bioengineering, or a related scientific discipline with 5+ years of hands-on industry experience (or equivalent combination of education and experience).HPLC Method Development: Demonstrated hands-on experience in developing analytical methods using gradient-elution High-Performance Liquid Chromatography (HPLC) modalities, specifically Reverse-Phase (RP), Ion-Pair Reverse-Phase (IPRP), or Anion-Exchange (AEX) chromatography.LNP / Nucleic Acid Expertise: Direct experience working with novel delivery systems, specifically Lipid Nanoparticles (LNPs), RNA, mRNA, or nucleic acid-based pharmaceuticals.Preferred / Nice-to-HaveBiophysical Characterization: Hands-on experience with Biolayer Interferometry (BLI) (e.g., Octet systems) or Surface Plasmon Resonance (SPR) (e.g., Biacore) for binding/kinetics characterization.Mass Spectrometry: Practical experience or exposure to Liquid Chromatography-Mass Spectrometry (LC-MS / LCMS) techniques.Data Analysis Software: Proficiency with advanced analytical and statistical software packages such as GraphPad Prism or JMP, in addition to advanced Microsoft Excel capabilities.