Senior Director, ITPacBio is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.The Senior Director, IT is responsible for leading the global IT organization at PacBio, encompassing teams that support enterprise, financial, manufacturing, and R&D information systems. This is a highly visible, cross-functional leadership role that partners closely with executive leadership and stakeholders across the company to enable business strategy, operational excellence, and innovation through secure, scalable, and compliant technology solutions.This role is ideal for an experienced IT leader with a strong background in life sciences and public-company environments, deep expertise in regulated systems, and a demonstrated ability to balance strategic vision with operational execution. Cybersecurity, risk management, compliance and management of IT operations and business applications teams are core responsibilities of this role.Responsibilities:Lead, develop, and scale a high-performing IT organization, including managers and senior technical leaders.Foster a culture of accountability, service excellence, security awareness, and continuous improvement.Define and execute a multi-year IT strategy and technology roadmap aligned with PacBio's business objectives.Partner closely with Finance, Manufacturing, R&D, Quality, Legal, and Commercial teams to support business needs and continually improve operational efficiency.Own PacBio's cybersecurity strategy, posture, and operations, including prevention, detection, response, and recovery.Ensure compliance with ISO 27001, SOX, and other applicable regulatory and audit requirements, including leading, coordinating, and interfacing directly with internal and external SOX auditors.Lead IT risk management, security governance, incident response planning, and third-party risk management.Establish and maintain security policies, standards, and controls across infrastructure, applications, and data.Partner with internal and external auditors to support audits and remediation activities.Ensure IT systems supporting regulated processes comply with validation and quality requirements (e.g., GxP).Own IT governance frameworks, including SDLC, change management, access controls, and data governance.Maintain audit readiness and documentation across systems and processes. Oversee enterprise architecture, application portfolio management, and system lifecycle planning.Lead the operation and evolution of hybrid infrastructure, including on-premises and cloud environments.Support high-performance computing (HPC) and large-scale storage platforms for R&D and data-intensive workloads.Drive reliability, scalability, and performance of mission-critical systems.Drive modernization initiatives, including cloud adoption, automation, and legacy system rationalization.Own the IT budget, forecasting, and cost optimization initiatives.Manage strategic vendor relationships, system integrators, and managed service providers.Required Qualifications:Bachelor's degree in Information Systems, Computer Science, Engineering, or a related field; advanced degree preferred.12+ years of progressive IT experience, including significant leadership at the director or senior director level.Experience in a public company, preferably within life sciences, biotechnology, or a regulated industry.Demonstrated experience with SOX compliance, remediation, and internal/external audits.Hands-on leadership experience with ISO 27001 security frameworks and certification efforts.Strong knowledge of system validation, enterprise architecture, application management, and IT governance.Proven experience managing hybrid IT environments, including cloud, on-premises infrastructure, HPC, and storage.Experience with and understanding of Jira Service Desk, SAP, Anaplan, Salesforce, PLM, and MES (Siemens Opcenter).Provide strategic oversight and guidance for PacBio's SAP ERP platform, ensuring alignment with business objectives, compliance requirements, and enterprise architecture standards.Excellent executive communication skills and ability to influence across functions.Preferred Experience:CISSP or equivalent cybersecurity certification strongly desired.Experience taking mature organizations through ISO 27001 certification.Experience supporting manufacturing, laboratory, and R&D systems in regulated environments.Familiarity with data privacy regulations and global security standards.Track record of leading IT and security transformations at scale.Candidates must have current authorization to work in the United States without the need for present or future sponsorship.Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite.You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.Salary Range: $195,900.00 - $293,900.00If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or for assistance.