Scientist II - HPLC Method Development

Position Title: Scientist II - Analytical

Work Location: San Diego, CA, 92111 (No relocations)

Assignment Duration: 6 month contract, with extensions possible

Work Arrangement: Onsite

Position Summary:

The Organization is searching for an outstanding Scientist II to join the Gene Medicines team in San Diego, CA. This position offers an exciting opportunity to work with new non-viral nucleic acid delivery tools for in vivo genome editing and gene therapy applications. This person will be engaged in the analysis of novel lipid nanoparticle-based pharmaceuticals.

Key Responsibilities:

• Work at the direction of Analytical scientists to analyze lipid nanoparticles (LNPs) encapsulating nucleic acids and LNP components using HPLC and Biolayer Interferometry (BLI)

• Develop methods to characterize LNPs and LNP components

• Establish relationships between physiochemical characteristics of experimental nanoparticle formulations and their efficacy and safety

• Maintain detailed records of analytical data

• Interface directly with other functional teams

• Share responsibility for basic lab management activities (supply ordering, instrument calibration, maintaining schedules)

Qualification & Experience:

• Master’s or Bachelor’s degree with 5+ years experience in pharmaceutical sciences, bioengineering, chemical engineering, chemistry, or related scientific discipline (an equivalent combination of education and experience may be considered).

• Experience developing methods in gradient-elution HPLC modalities such as RP, IPRP, or AEX is required

• Experience with BLI or Surface Plasmon Resonance (SPR) is highly desirable

• Experience with LCMS is desirable

• Excellent attention to detail and ability to produce consistent results and effectively communicate them to the team

• Ability to be a team player, multitask and work on multiple projects at once, and excel in a collaborative work environment.

• Proficiency at MS Excel is required; prior experience with advanced analytical software (Prism, JMP) is desirable

• Excellent oral and written communication skills

Applicant Notices & Disclaimers

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At SPECTRAFORCE, we are committed to maintaining a workplace that ensures fair compensation and wage transparency in adherence with all applicable state and local laws.